The occurrence of the Formosa Fun Coast explosion once again highlighted the need for the government to review rescue and medical systems, as well as the means for managing security problems when dealing with large-scale disaster prevention and relief activities. This study focused on how the New Taipei City government dealt with the Formosa Fun Coast explosion incident, using the three-phase theory of crisis management and a literature review, case studies, and in-depth interviews with emergency professionals involved in the case to investigate the crisis management and emergency response capabilities of various government departments and learn valuable lessons from the experience. The study concludes by making five proposals, namely, that the relevant laws and regulations for disaster prevention and relief should be amended, that the awareness of the public regarding security matters should be enhanced, that safety management regulations for large-scale activities should be revised and reissued, that a platform for emergency medical rescues during disasters should be constructed, and that dedicated units for disaster prevention and relief should be established, with the hope that these proposed changes could help the government be better prepared to face similar events in the future.