The influence of culture that of national heritage, organizational membership, and professional allegiances, is apparent in airline operation. This cross-cultural study documents the cross-cultural differences between an U.S. and Taiwanese airlines. Methodologies involved utilization of open-ended questions in individual interviews, thematic analysis, and narrative analysis. Both airlines exhibited tendencies and policy-making shaped by the influence of national heritage. Professional allegiance produced parity only in matters related to pilot traits which is consistent with the results of standardized CRM training. The results may have applied value for airline operation composed of multi-cultural work force competing in international arena.